Autoimmune disease and GUT
Autoimmune diseases like rheumatoid arthritis (RA) can be challenging to manage because

they involve the immune system attacking healthy tissues in the body. Recent research has
shown that gut health can play a significant role in the development and management of
autoimmune diseases, including RA.
In this article, we'll explore the connection between gut health and autoimmune diseases and
what steps you can take to support your gut health and reduce your RA symptoms.
The Gut Microbiome and Autoimmune Diseases:
The gut microbiome is a collection of microorganisms that live in our intestines and play a
critical role in our health.
Research has shown that the gut microbiome can influence the immune system and the
development of autoimmune diseases like RA. When the gut microbiome is imbalanced, with an
overgrowth of harmful bacteria and a lack of beneficial bacteria, it can lead to chronic
inflammation and a weakened immune system.
This inflammation can trigger the development of autoimmune diseases and worsen existing
symptoms.
Studies have found that individuals with RA tend to have imbalances in their gut microbiome,
with a lower diversity of bacteria and a higher abundance of harmful bacteria. This dysbiosis in
the gut microbiome can increase inflammation and damage to joints, exacerbating RA
symptoms.
Leaky Gut and Autoimmune Diseases:
Another important aspect of gut health that can contribute to autoimmune diseases like RA is
intestinal permeability, also known as leaky gut. When the lining of the gut becomes damaged, it
can allow harmful substances like toxins and undigested food particles to leak into the
bloodstream. This triggers an immune response, leading to chronic inflammation and the
development of autoimmune diseases.
A leaky gut has been linked to several autoimmune diseases, including RA. In one study,
researchers found that individuals with RA had higher levels of a protein called zonulin, which is
associated with increased intestinal permeability. It may be possible to reduce inflammation and
manage autoimmune diseases like RA by supporting gut health and reducing intestinal
permeability.